A multilocular thymic cyst associated with mediastinal seminoma: evidence for its medullary epithelial origin highlighted by POU2F3-positive thymic tuft cells and concomitant myoid cell proliferation

نویسندگان

چکیده

Multilocular thymic cyst (MTC) and germ cell tumors are common diseases that impact the mediastinum. Correctly diagnosing these can be difficult because several other conditions mimic them. We report a male patient with MTC associated mediastinal seminoma. A needle biopsy of tumor revealed numerous epithelioid granulomas mimicked sarcoidosis or mycobacterial infection. However, large atypical cells positive for Oct3/4 KIT were noted between granulomas; thus, we diagnosed The resected tumor, after chemotherapy, consisted multiple cystic lesions, residual was first considered. medulla-specific elements, namely, POU2F3-positive tuft rhabdomyomatous myoid accompanying epithelium, led to correct diagnosis MTC. Our case underscores importance recognizing histological features seminoma provides novel findings pathogenesis, presence cells.

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ژورنال

عنوان ژورنال: Virchows Archiv

سال: 2021

ISSN: ['0945-6317', '1432-2307']

DOI: https://doi.org/10.1007/s00428-021-03125-2